Michelle Marasco, Ph.D.

Assistant Professor of Biology

Programs: Biology, Clinical Laboratory Science, Forensic Science, Molecular Biology, Restoration Ecology

Phone: 419-783-2593

Email: mmarasco@defiance.edu

Michelle Marasco

TEACHING INTERESTS

Introductory biology, zoology, evolution, developmental biology

RESEARCH EXPERIENCES

Postdoctoral research on cell biology and diabetes, Indiana University School of Medicine, Indianapolis, IN 2017-2020.

Doctoral graduate studies on biochemistry and epigenetics, Indiana University, Bloomington, IN 2010-2017.

Research on pharmaceutical biomarkers, Eli Lilly and Company, Indianapolis, IN 2006-2010.

Master's graduate studies on development, University of Utah, Salt Lake City, UT 2003-2005.

Undergraduate research on bacterial division, Hanover College, Hanover, IN 2001-2003.

Undergraduate research on ecology and evolution, Hanover College, Hanover, IN 2002.

Summer Undergraduate research on physiology, University of Louisville, Louisville, KY 2001.

PUBLICATIONS

Michelle R. Marasco, Abass M. Conteh, Christopher A. Reissaus, John E. Cupit V, Evan M. Appleman, Raghavendra G. Mirmira and Amelia K. Linnemann. 2018. Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy with the Antioxidant Response. Diabetes. 67:1-13.

Michelle R. Marasco and Amelia K. Linnemann. 2018. β-Cell Autophagy in Diabetes Pathogenesis. Endocrinology. 159(5):2127-2141.

Michelle Marasco, Weiyi Li, Michael Lynch, and Craig S. Pikaard. 2017. Catalytic properties of RNA polymerases IV and V: accuracy, nucleotide incorporation and rNTP/dNTP discrimination. Nucleic Acids Research. 45(19):11315-11326.

Amelia K. Linnemann, Joseph Blumer, Michelle R. Marasco, Therese J. Battiola, Heidi M. Umhoefer, Jee Young Han, Dudley W. Lamming, and Dawn Belt Davis. 2017. Interleukin 6 Protects Pancreatic β-cells from Apoptosis by Stimulation of Autophagy. FASEB J. 31(9):41404152.

Todd Blevins, Ram Podicheti, Vibhor Mishra, Michelle Marasco, Jing Wang, Douglas Rusch, Haixu Tang, Craig S Pikaard. (2015). Identification of Pol IV and RDR2-dependent precursors of 24 nt siRNAs guiding de novo DNA methylation in Arabidopsis. eLife. 10.7554/eLife.09591.

Jeremy R. Haag, Thomas S. Ream, Michelle Marasco, Carrie D. Nicora, Angela D. Norbeck, Ljiljana PasaTolic and Craig S. Pikaard (2012). In vitro transcription activities of Pol IV, Pol V and RDR2 reveal coupling of Pol IV and RDR2 for dsRNA synthesis in plant RNA silencing. Molecular Cell. 48: 811-818.

Liu W, Downing AM, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK. (2010). Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia. Pharmacogenomics J. 12(3): 246-254.

ORAL PRESENTATIONS

Michelle R. Marasco, Abass M. Conteh, Charanya Muralidharan, Elizabeth Pfiefer, Amelia K. Linnemann. IL6 protects pancreatic β-cells from oxidative stress via NRF2 mitochondrial translocation and mitophagy. 79th Scientific Sessions of the American Diabetes Association. June 9, 2019 in San Francisco, CA.

Michelle R. Marasco, Abass M. Conteh, Christopher A. Reissaus, John E. Cupit V, Evan M. Appleman, Raghavendra G. Mirmira, and Amelia K. Linnemann. IL-6 stimulation of autophagy and the antioxidant response protects β-cells from oxidative stress. 11th Annual Midwest Islet Club. May 14-15, 2018 in St. Louis, MO.

Michelle R. Marasco, Adwait Sadwilkar, David Wong, Paul Miller, Amelia K. Linnemann. IL-6 links autophagy to antioxidant response in the pancreatic β-cell. 10th Annual Midwest Islet Club. May 25-26, 2017 in Madison, WI.

Michelle Marasco and Craig Pikaard. Catalytic properties of multisubunit RNA polymerases IV and V: the price of sequence divergence, relative to Pol II, on transcriptional accuracy and elongation rate. International Conference on Transcription by RNA Polymerases I, III, IV, and V: OddPols 2016. June 24-27, 2016 in Ann Arbor, MI.

Michelle Marasco and Craig Pikaard. Dramatic active site divergence in multi-subunit RNA polymerases IV Michelle R. Marasco reedmir@iu.edu and V: does it make them error-prone? International Conference on Transcription by RNA Polymerases I, III, IV, and V: OddPols 2014. June 19-21, 2014 in Ann Arbor, MI.

Michelle Reed and Jeff Hughes. Role of S-Adenosyl Methionine in Bacterial Cell Division. Butler Undergraduate Research conference. 2002 in Indianapolis, IN.

POSTER PRESENTATIONS

Michelle R. Marasco, Abass M. Conteh, Charanya Muralidharan, Amelia K. Linnemann. IL-6 family cytokines stimulate mitophagy associated with a noncanonical translocation of the antioxidant factor NRF2 to the mitochondria in beta cells. Keystone Islet Biology: From Gene to Cell to Micro-Organ. January 27 - 31, 2020 in Santa Fe, New Mexico.

Michelle R. Marasco, Abass M. Conteh, Charanya Muralidharan, Elizabeth Pfiefer, Amelia K. Linnemann. Investigation of the mechanism through which IL-6 regulates NRF2 mitochondrial translocation. 12th Annual Midwest Islet Club. May 19-20, 2019 in Ann Arbor, Michigan.

Michelle R. Marasco, Abass M. Conteh, Christopher A. Reissaus, John E. Cupit IV, Evan M. Appleman, Raghavendra G. Mirmira, Amelia K. Linnemann. IL-6 stimulates autophagy and the antioxidant response to protect the pancreatic beta-cell from oxidative stress. 100th Endocrine Society Meeting. March 17-20, 2018 in Chicago, IL.

Michelle R. Reed, Cara Ruble, Catalina Lopez-Correa, Katherine T. Landschulz, Anne ReifelMiller. Evidence for Alternative Transcription Start Sites in TCF7L2: Potential Mechanism through Which TCF7L2 Genetic Variants Increase Risk of Type II Diabetes. Keystone Symposia on Type II Diabetes and Insulin Resistance. January 2009 in Banff, Alberta.

M.R. Reed, J.A. Roseberry Baker, G. Zhao, C. Lopez-Correa. Development of a Clinical Biomarker Assay for the t(4;14) Translocation Associated with Multiple Myeloma. American Society of Human Genetics. October 2007 in San Diego, California.

Michelle Reed and Jeff Hughes. Role of S-Adenosyl Methionine in Bacterial Cell Division. Indiana Branch of the American Society for Microbiology meeting. 2003 in Bloomington, IN.

AWARDS & HONORS

Certificate of Excellence in Research, Indiana University School of Medicine, 2019
Winner of Indiana University School of Medicine Wells Center Retreat oral presentation competition, 2019
Invited to compete in the Endocrine Society's Presidential Poster Competition, 2018
Laboratory of Experimental Medicine Scientific Achievement Award, 2009
Hanover College Junior Biology Major of the Year, 2002
Lilly Foundation Community Scholarship, 1999-2003

ACADEMIC DEGREES

Ph.D. in Genome, Cell, and Developmental Biology, Indiana University (2017)
M.S. in Human Genetics, University of Utah (2005)
B.A. in Biology, Hanover College (2003)