| Date | Location | Result | |
| 04-04-08 | Amelia, OH | Mount St. Joseph 9, Defiance College 7 | Box score |
| 05-03-08 | Amelia, OH | Mount St. Joseph 15, Defiance College 13 | Box score |
| 05-03-08 | Amelia, OH | Mount St. Joseph 7, Defiance College 2 | Box score |
| 04-29-08 | Defiance, OH | Ohio Northern 6, Defiance College 5 | Box score |
| 04-26-08 | Defiance, OH | Anderson 28, Defiance College 8 | Box score |
| 04-26-08 | Defiance, OH | Anderson 23, Defiance College 2 | Box score |
| 04-25-08 | Anderson, IN | Anderson 16, Defiance 12 | Box score |
| 04-23-08 | Springfield, OH | Wittenberg Tigers 17, Defiance College 4 | Box score |
| 04-22-08 | Defiance, OH | Bluffton 10, Defiance College 9 | Box score |
| 04-19-08 | Defiance, OH | Rose-Hulman 13, Defiance College 1 | Box score |
| 04-19-08 | Defiance, OH | Rose-Hulman 12, Defiance College 0 | Box score |
| 04-18-08 | Defiance, OH | Rose-Hulman 18, Defiance College 7 | Box score |
| 04-15-08 | Defiance, OH | Manchester College 7, Defiance College 5 | Box score |
| 04-12-08 | Hanover, IN | Defiance College 9, Hanover College 3 | Box score |
| 04-12-08 | Hanover, IN | Hanover College 5, Defiance College 2 | Box score |
| 04-11-08 | Hanover, IN | Hanover College 7, Defiance College 6 | Box score |
| 04-08-08 | Bluffton, OH | Bluffton 8, Defiance College 3 | Box score |
| 04-06-08 | Defiance, OH | Transylvania 4, Defiance College 0 | Box score |
| 04-05-08 | Defiance, OH | Transylvania 8, Defiance College 2 | Box score |
| 04-05-08 | Defiance, OH | Transylvania 6, Defiance College 2 | Box score |
| 04-01-08 | Ada, OH | Defiance 8, Ohio Northern 6 | Box score |
| 03-25-08 | N. Manchester, IN | Manchester 21, Defiance 8 | Box score |
| 03-22-08 | Franklin, IN | Franklin 5, Defiance College 2 | Box score |
| 03-22-08 | Franklin, IN | Franklin 8, Defiance College 2 | Box score |
| 03-21-08 | Franklin, IN | Franklin 22, Defiance College 0 | Box score |
| 03-14-08 | Port Charlotte, FL | Ohio Wesleyan 9, Defiance 3 | Box score |
| 03-14-08 | Port Charlotte, FL | Ohio Wesleyan 7, Defiance 3 | Box score |
| 03-13-08 | Port Charlotte, FL | Defiance 3, Albion 2 | Box score |
| 03-12-08 | Port Charlotte, FL | Defiance 9, Olivet 6 | Box score |
| 03-12-08 | Port Charlotte, FL | Defiance 15, Olivet 9 | Box score |
| 03-11-08 | Port Charlotte, FL | Wentworth 3, Defiance 2 | Box score |
| 03-10-08 | Port Charlotte, FL | Wentworth 6, Defiance 5 | Box score |
| 03-10-08 | Port Charlotte, FL | Wentworth 5, Defiance 2 | Box score |