| Date | Location | Result | |
| 02-23-08 | Karl H. Weaner Center - Defiance, Ohio | Defiance College 83, Rose-Hulman 61 | Box score |
| 02-20-08 | Karl H. Weaner Center - Defiance, Ohio | Defiance College 79, Franklin College 68 | Box score |
| 02-16-08 | Karl H. Weaner Center - Defiance, Ohio | Transylvania University 80, Defiance College 71 | Box score |
| 02-13-08 | Karl H. Weaner Center - Defiance, Ohio | Manchester College 74, Defiance College 64 | Box score |
| 02-09-08 | Hulbert Arena - Terre Haute, Ind. | Rose-Hulman 75, Defiance 65 | Box score |
| 02-06-08 | Defiance, Ohio - Karl H. Weaner Center | Defiance College 116, Taylor University-Fort Wayne 62 | Box score |
| 02-02-08 | Defiance, Ohio - Karl H. Weaner Center | Defiance College 72, Mount St. Joseph 63 | Box score |
| 1-30-08 | Bluffton, Ohio (Founders Hall) | Bluffton University 80, Defiance College 77 | Box score |
| 01-26-08 | Defiance, Ohio - Karl H. Weaner Center | Hanover College 62, Defiance College 60 | Box score |
| 01-23-08 | Manchester College | Manchester College 67, Defiance 61 | Box score |
| 01-19-08 | Defiance, Ohio - Karl H. Weaner Center | Anderson University 84, Defiance College 64 | Box score |
| 01-16-08 | Spurlock Center; Franklin, Ind. | Franklin College 73, Defiance College 61 | Box score |
| 01-12-08 | Lexington, Ky. (Beck Center) | DEFIANCE 80, Transylvania 68 | Box score |
| 1-5-08 | Harrington Center (MSJ) Cincinnati, OH | College of Mount St. Joseph 69, Defiance College 58 | Box score |
| 01-02-08 | Defiance, Ohio - Karl H. Weaner Center | Defiance College 92, Tri-State University 80 | Box score |
| 12/29/07 | The Capital Center - Columbus, Ohio | Capital 80, Defiance 70 | Box score |
| 12-17-07 | Karl H. Weaner Center - Defiance, Ohio | Defiance College 86, Wilberforce University 79 | Box score |
| 12-15-07 | Karl H. Weaner Center - Defiance, Ohio | Milligan College 108, Defiance College 80 | Box score |
| 12-14-07 | Karl H. Weaner Center - Defiance, Ohio | Defiance College 80, Marygrove College 57 | Box score |
| 12-08-07 | Collier Arena - Hanover, Ind. | Hanover 77, Defiance 64 | Box score |
| 12-5-07 | Defiance, Ohio | Defiance College 68, Bluffton University 65 | Box score |
| 12-1-07 | O.C. Lewis Gymnasium, Anderson, Ind. | Anderson University 85, Defiance 66 | Box score |
| 11-21-07 | Defiance, Ohio | Hope College 93, Defiance College 70 | Box score |
| 11-17-07 | Defiance, Ohio | Defiance College 76, Siena Heights University 66 | Box score |